We begin with the Covid-19 pandemic as the daily number of new coronavirus cases passes the 150-thousand mark for the first time. CBS’s David Begnaud with more. CBS News Medical Contributor Dr. David Agus joins Allison to speak about exciting Covid-19 medical advances this week, including a new vaccine from Pfizer the company says is 90 percent effective. The nation and the world are watching the chaotic transition between outgoing President Trump and incoming President-elect Joe Biden. Allison asks Mark Medish, former member of former President Clinton’s administration and co-founder of the non-profit, non-partisan Keep Our Republic election integrity group, what he thinks about all of this.  CBS’s Sabina Castelfranco joins Allison to explain. AAA estimates that tens of millions will travel this Thanksgiving holiday despite the coronavirus pandemic. CBS’s Kris Van Cleave reports this is leading to worries about an even larger Covid-19 surge, and also discusses the safety of flying. The nation’s top infectious disease expert, Dr. Anthony Fauci, says if people are having a holiday gathering they should mask up. In this week’s Kaleidoscope segment, we look at what many are calling the “Rainbow Wave” of LGBTQ+ election day victories across the nation. Allison speaks with 27-year-old Mauree Turner, the first Muslim and first non-binary person elected to the State House in Oklahoma.